Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation
Src-family kinases Fyn and Lyn are signaling components downstream of ITAM-bearing antigen receptors. Here the authors show that by phosphorylating SHP-1 at different residues, Lyn and Fyn can have opposing regulatory effects on ITAM receptors.
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Auteurs principaux: | , , , , , , , , , , , |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2017
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Sujets: | |
Accès en ligne: | https://doaj.org/article/018c8dd96b534ef981f995c3443a4374 |
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