Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation

Src-family kinases Fyn and Lyn are signaling components downstream of ITAM-bearing antigen receptors. Here the authors show that by phosphorylating SHP-1 at different residues, Lyn and Fyn can have opposing regulatory effects on ITAM receptors.

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Autores principales:	Sanae Ben Mkaddem, Amaya Murua, Héloise Flament, Dimitri Titeca-Beauport, Carine Bounaix, Luca Danelli, Pierre Launay, Marc Benhamou, Ulrich Blank, Eric Daugas, Nicolas Charles, Renato C. Monteiro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/018c8dd96b534ef981f995c3443a4374
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spelling	oai:doaj.org-article:018c8dd96b534ef981f995c3443a43742021-12-02T14:16:55ZLyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation10.1038/s41467-017-00294-02041-1723https://doaj.org/article/018c8dd96b534ef981f995c3443a43742017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00294-0https://doaj.org/toc/2041-1723Src-family kinases Fyn and Lyn are signaling components downstream of ITAM-bearing antigen receptors. Here the authors show that by phosphorylating SHP-1 at different residues, Lyn and Fyn can have opposing regulatory effects on ITAM receptors.Sanae Ben MkaddemAmaya MuruaHéloise FlamentDimitri Titeca-BeauportCarine BounaixLuca DanelliPierre LaunayMarc BenhamouUlrich BlankEric DaugasNicolas CharlesRenato C. MonteiroNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sanae Ben Mkaddem Amaya Murua Héloise Flament Dimitri Titeca-Beauport Carine Bounaix Luca Danelli Pierre Launay Marc Benhamou Ulrich Blank Eric Daugas Nicolas Charles Renato C. Monteiro Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation
description	Src-family kinases Fyn and Lyn are signaling components downstream of ITAM-bearing antigen receptors. Here the authors show that by phosphorylating SHP-1 at different residues, Lyn and Fyn can have opposing regulatory effects on ITAM receptors.
format	article
author	Sanae Ben Mkaddem Amaya Murua Héloise Flament Dimitri Titeca-Beauport Carine Bounaix Luca Danelli Pierre Launay Marc Benhamou Ulrich Blank Eric Daugas Nicolas Charles Renato C. Monteiro
author_facet	Sanae Ben Mkaddem Amaya Murua Héloise Flament Dimitri Titeca-Beauport Carine Bounaix Luca Danelli Pierre Launay Marc Benhamou Ulrich Blank Eric Daugas Nicolas Charles Renato C. Monteiro
author_sort	Sanae Ben Mkaddem
title	Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation
title_short	Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation
title_full	Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation
title_fullStr	Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation
title_full_unstemmed	Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation
title_sort	lyn and fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/018c8dd96b534ef981f995c3443a4374
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Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation

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