Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis

Population structure can bias the results of genetic and epidemiological analysis. Here, Haworth et al. report that fine-scale structure is detectable in apparently homogeneous samples such as ALSPAC when measured very precisely, and remains detectable in UK Biobank despite conventional approaches t...

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Autores principales:	Simon Haworth, Ruth Mitchell, Laura Corbin, Kaitlin H. Wade, Tom Dudding, Ashley Budu-Aggrey, David Carslake, Gibran Hemani, Lavinia Paternoster, George Davey Smith, Neil Davies, Daniel J. Lawson, Nicholas J. Timpson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/019488528e71499c94f143f53d999f6f
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spelling	oai:doaj.org-article:019488528e71499c94f143f53d999f6f2021-12-02T14:40:21ZApparent latent structure within the UK Biobank sample has implications for epidemiological analysis10.1038/s41467-018-08219-12041-1723https://doaj.org/article/019488528e71499c94f143f53d999f6f2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08219-1https://doaj.org/toc/2041-1723Population structure can bias the results of genetic and epidemiological analysis. Here, Haworth et al. report that fine-scale structure is detectable in apparently homogeneous samples such as ALSPAC when measured very precisely, and remains detectable in UK Biobank despite conventional approaches to account for it.Simon HaworthRuth MitchellLaura CorbinKaitlin H. WadeTom DuddingAshley Budu-AggreyDavid CarslakeGibran HemaniLavinia PaternosterGeorge Davey SmithNeil DaviesDaniel J. LawsonNicholas J. TimpsonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simon Haworth Ruth Mitchell Laura Corbin Kaitlin H. Wade Tom Dudding Ashley Budu-Aggrey David Carslake Gibran Hemani Lavinia Paternoster George Davey Smith Neil Davies Daniel J. Lawson Nicholas J. Timpson Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis
description	Population structure can bias the results of genetic and epidemiological analysis. Here, Haworth et al. report that fine-scale structure is detectable in apparently homogeneous samples such as ALSPAC when measured very precisely, and remains detectable in UK Biobank despite conventional approaches to account for it.
format	article
author	Simon Haworth Ruth Mitchell Laura Corbin Kaitlin H. Wade Tom Dudding Ashley Budu-Aggrey David Carslake Gibran Hemani Lavinia Paternoster George Davey Smith Neil Davies Daniel J. Lawson Nicholas J. Timpson
author_facet	Simon Haworth Ruth Mitchell Laura Corbin Kaitlin H. Wade Tom Dudding Ashley Budu-Aggrey David Carslake Gibran Hemani Lavinia Paternoster George Davey Smith Neil Davies Daniel J. Lawson Nicholas J. Timpson
author_sort	Simon Haworth
title	Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis
title_short	Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis
title_full	Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis
title_fullStr	Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis
title_full_unstemmed	Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis
title_sort	apparent latent structure within the uk biobank sample has implications for epidemiological analysis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/019488528e71499c94f143f53d999f6f
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Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis

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