Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration

Adenomatous polyposis coli (APC) regulates the localization of some mRNAs at cellular protrusions but the underlying mechanisms and functional roles are not known. Here the authors show that APC-dependent RNAs are enriched in contractile protrusions, via detyrosinated microtubules, and enhance cell...

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Autores principales: Tianhong Wang, Susan Hamilla, Maggie Cam, Helim Aranda-Espinoza, Stavroula Mili
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/01bd1431351c4daf8043cc31fd4e3426
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