Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration

Adenomatous polyposis coli (APC) regulates the localization of some mRNAs at cellular protrusions but the underlying mechanisms and functional roles are not known. Here the authors show that APC-dependent RNAs are enriched in contractile protrusions, via detyrosinated microtubules, and enhance cell...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tianhong Wang, Susan Hamilla, Maggie Cam, Helim Aranda-Espinoza, Stavroula Mili
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/01bd1431351c4daf8043cc31fd4e3426
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:01bd1431351c4daf8043cc31fd4e3426
record_format	dspace
spelling	oai:doaj.org-article:01bd1431351c4daf8043cc31fd4e34262021-12-02T15:38:33ZExtracellular matrix stiffness and cell contractility control RNA localization to promote cell migration10.1038/s41467-017-00884-y2041-1723https://doaj.org/article/01bd1431351c4daf8043cc31fd4e34262017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00884-yhttps://doaj.org/toc/2041-1723Adenomatous polyposis coli (APC) regulates the localization of some mRNAs at cellular protrusions but the underlying mechanisms and functional roles are not known. Here the authors show that APC-dependent RNAs are enriched in contractile protrusions, via detyrosinated microtubules, and enhance cell migration.Tianhong WangSusan HamillaMaggie CamHelim Aranda-EspinozaStavroula MiliNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tianhong Wang Susan Hamilla Maggie Cam Helim Aranda-Espinoza Stavroula Mili Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration
description	Adenomatous polyposis coli (APC) regulates the localization of some mRNAs at cellular protrusions but the underlying mechanisms and functional roles are not known. Here the authors show that APC-dependent RNAs are enriched in contractile protrusions, via detyrosinated microtubules, and enhance cell migration.
format	article
author	Tianhong Wang Susan Hamilla Maggie Cam Helim Aranda-Espinoza Stavroula Mili
author_facet	Tianhong Wang Susan Hamilla Maggie Cam Helim Aranda-Espinoza Stavroula Mili
author_sort	Tianhong Wang
title	Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration
title_short	Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration
title_full	Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration
title_fullStr	Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration
title_full_unstemmed	Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration
title_sort	extracellular matrix stiffness and cell contractility control rna localization to promote cell migration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/01bd1431351c4daf8043cc31fd4e3426
work_keys_str_mv	AT tianhongwang extracellularmatrixstiffnessandcellcontractilitycontrolrnalocalizationtopromotecellmigration AT susanhamilla extracellularmatrixstiffnessandcellcontractilitycontrolrnalocalizationtopromotecellmigration AT maggiecam extracellularmatrixstiffnessandcellcontractilitycontrolrnalocalizationtopromotecellmigration AT helimarandaespinoza extracellularmatrixstiffnessandcellcontractilitycontrolrnalocalizationtopromotecellmigration AT stavroulamili extracellularmatrixstiffnessandcellcontractilitycontrolrnalocalizationtopromotecellmigration
_version_	1718386151513915392

Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration

Ejemplares similares