3D replicon distributions arise from stochastic initiation and domino-like DNA replication progression

DNA replication in higher eukaryotes is a complex process occurring in a complex genome environment. Here the authors present a model of DNA replication that incorporates random loop chromatin folding and domino-like fork progression reproducing the spatial and temporal characteristics of S-phase.

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Autores principales: D. Löb, N. Lengert, V. O. Chagin, M. Reinhart, C. S. Casas-Delucchi, M. C. Cardoso, B. Drossel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/01dc71825b0b419da1a3f0217211fc56
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