Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites

Src is a prototypical signaling non-receptor protein tyrosine kinase that interconverts between distinct conformations. Here the authors use variants of the kinase-inhibitor dasatinib to define three specific conformational states of the Src kinase and shed insight on the effect of conformation-spec...

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Auteurs principaux: Michael Tong, Jeff G. Pelton, Michelle L. Gill, Weibing Zhang, Francis Picart, Markus A. Seeliger
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Accès en ligne:https://doaj.org/article/01dc8ef23c534552afe3e1801c1b9be5
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