Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites

Src is a prototypical signaling non-receptor protein tyrosine kinase that interconverts between distinct conformations. Here the authors use variants of the kinase-inhibitor dasatinib to define three specific conformational states of the Src kinase and shed insight on the effect of conformation-spec...

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Autores principales:	Michael Tong, Jeff G. Pelton, Michelle L. Gill, Weibing Zhang, Francis Picart, Markus A. Seeliger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/01dc8ef23c534552afe3e1801c1b9be5
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spelling	oai:doaj.org-article:01dc8ef23c534552afe3e1801c1b9be52021-12-02T15:38:50ZSurvey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites10.1038/s41467-017-02240-62041-1723https://doaj.org/article/01dc8ef23c534552afe3e1801c1b9be52017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02240-6https://doaj.org/toc/2041-1723Src is a prototypical signaling non-receptor protein tyrosine kinase that interconverts between distinct conformations. Here the authors use variants of the kinase-inhibitor dasatinib to define three specific conformational states of the Src kinase and shed insight on the effect of conformation-specific inhibitors on Src dynamics.Michael TongJeff G. PeltonMichelle L. GillWeibing ZhangFrancis PicartMarkus A. SeeligerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Tong Jeff G. Pelton Michelle L. Gill Weibing Zhang Francis Picart Markus A. Seeliger Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites
description	Src is a prototypical signaling non-receptor protein tyrosine kinase that interconverts between distinct conformations. Here the authors use variants of the kinase-inhibitor dasatinib to define three specific conformational states of the Src kinase and shed insight on the effect of conformation-specific inhibitors on Src dynamics.
format	article
author	Michael Tong Jeff G. Pelton Michelle L. Gill Weibing Zhang Francis Picart Markus A. Seeliger
author_facet	Michael Tong Jeff G. Pelton Michelle L. Gill Weibing Zhang Francis Picart Markus A. Seeliger
author_sort	Michael Tong
title	Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites
title_short	Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites
title_full	Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites
title_fullStr	Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites
title_full_unstemmed	Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites
title_sort	survey of solution dynamics in src kinase reveals allosteric cross talk between the ligand binding and regulatory sites
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/01dc8ef23c534552afe3e1801c1b9be5
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Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites

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