Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain

Airah Javorsky et al. present the crystal structures of SARS-CoV-1 and SARS-CoV-2 E proteins in complex with the PALS1 PDZ domain. Their results suggest that the coronavirus E protein can interfere with normal PALS1 binding, potentially disrupting epithelial tissue integrity, and may provide future...

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Autores principales: Airah Javorsky, Patrick O. Humbert, Marc Kvansakul
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/01e145d634fb42a783e337f538813dee
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