Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain

Airah Javorsky et al. present the crystal structures of SARS-CoV-1 and SARS-CoV-2 E proteins in complex with the PALS1 PDZ domain. Their results suggest that the coronavirus E protein can interfere with normal PALS1 binding, potentially disrupting epithelial tissue integrity, and may provide future...

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Autores principales:	Airah Javorsky, Patrick O. Humbert, Marc Kvansakul
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/01e145d634fb42a783e337f538813dee
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spelling	oai:doaj.org-article:01e145d634fb42a783e337f538813dee2021-12-02T15:02:51ZStructural basis of coronavirus E protein interactions with human PALS1 PDZ domain10.1038/s42003-021-02250-72399-3642https://doaj.org/article/01e145d634fb42a783e337f538813dee2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02250-7https://doaj.org/toc/2399-3642Airah Javorsky et al. present the crystal structures of SARS-CoV-1 and SARS-CoV-2 E proteins in complex with the PALS1 PDZ domain. Their results suggest that the coronavirus E protein can interfere with normal PALS1 binding, potentially disrupting epithelial tissue integrity, and may provide future insight into the development of small molecule inhibitors against SARS-CoV-1/2.Airah JavorskyPatrick O. HumbertMarc KvansakulNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Airah Javorsky Patrick O. Humbert Marc Kvansakul Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain
description	Airah Javorsky et al. present the crystal structures of SARS-CoV-1 and SARS-CoV-2 E proteins in complex with the PALS1 PDZ domain. Their results suggest that the coronavirus E protein can interfere with normal PALS1 binding, potentially disrupting epithelial tissue integrity, and may provide future insight into the development of small molecule inhibitors against SARS-CoV-1/2.
format	article
author	Airah Javorsky Patrick O. Humbert Marc Kvansakul
author_facet	Airah Javorsky Patrick O. Humbert Marc Kvansakul
author_sort	Airah Javorsky
title	Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain
title_short	Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain
title_full	Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain
title_fullStr	Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain
title_full_unstemmed	Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain
title_sort	structural basis of coronavirus e protein interactions with human pals1 pdz domain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/01e145d634fb42a783e337f538813dee
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Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain

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