Robust network topologies for generating switch-like cellular responses.

Signaling networks that convert graded stimuli into binary, all-or-none cellular responses are critical in processes ranging from cell-cycle control to lineage commitment. To exhaustively enumerate topologies that exhibit this switch-like behavior, we simulated all possible two- and three-component...

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Auteurs principaux: Najaf A Shah, Casim A Sarkar
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2011
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Accès en ligne:https://doaj.org/article/0206fdad440e40a9b0106ddad8d126a4
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