Robust network topologies for generating switch-like cellular responses.

Signaling networks that convert graded stimuli into binary, all-or-none cellular responses are critical in processes ranging from cell-cycle control to lineage commitment. To exhaustively enumerate topologies that exhibit this switch-like behavior, we simulated all possible two- and three-component...

Full description

Saved in:
Bibliographic Details
Main Authors: Najaf A Shah, Casim A Sarkar
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2011
Subjects:
Online Access:https://doaj.org/article/0206fdad440e40a9b0106ddad8d126a4
Tags: Add Tag
No Tags, Be the first to tag this record!