Tepotinib Inhibits Several Drug Efflux Transporters and Biotransformation Enzymes: The Role in Drug-Drug Interactions and Targeting Cytostatic Resistance In Vitro and Ex Vivo

Tepotinib Inhibits Several Drug Efflux Transporters and Biotransformation Enzymes: The Role in Drug-Drug Interactions and Targeting Cytostatic Resistance In Vitro and Ex Vivo

Tepotinib is a novel tyrosine kinase inhibitor recently approved for the treatment of non-small cell lung cancer (NSCLC). In this study, we evaluated the tepotinib’s potential to perpetrate pharmacokinetic drug interactions and modulate multidrug resistance (MDR). Accumulation studies showed that te...

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Bibliographic Details
Main Authors: Dimitrios Vagiannis, Youssif Budagaga, Anselm Morell, Yu Zhang, Eva Novotná, Adam Skarka, Sarah Kammerer, Jan-Heiner Küpper, Ivo Hanke, Tomáš Rozkoš, Jakub Hofman
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
tepotinib
non-small cell lung cancer
multidrug resistance
drug interaction
ABC transporter
cytochrome P450
Biology (General)
QH301-705.5
Chemistry
QD1-999
Online Access:https://doaj.org/article/0212eb51dc624676ad5bb0e9e6facdd1
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https://doaj.org/article/0212eb51dc624676ad5bb0e9e6facdd1

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