A motif within the armadillo repeat of Parkinson’s-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway
Abstract In experimental models, both in vivo and cellular, over-expression of Parkinson’s linked mutant leucine-rich repeat kinase 2 (LRRK2) is sufficient to induce neuronal death. While several cell death associated proteins have been linked to LRRK2, either as protein interactors or as putative s...
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Main Authors: | , , , , , , , , , , |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2018
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Subjects: | |
Online Access: | https://doaj.org/article/023f75cba7e141e794a505571ddc8b16 |
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