Berberine Derivatives as <i>Pseudomonas aeruginosa</i> MexXY-OprM Inhibitors: Activity and In Silico Insights

Berberine Derivatives as <i>Pseudomonas aeruginosa</i> MexXY-OprM Inhibitors: Activity and In Silico Insights

The natural alkaloid berberine has been demonstrated to inhibit the <i>Pseudomonas aeruginosa</i> multidrug efflux system MexXY-OprM, which is responsible for tobramycin extrusion by binding the inner membrane transporter MexY. To find a structure with improved inhibitory activity, we co...

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Autores principales: Giorgia Giorgini, Gianmarco Mangiaterra, Nicholas Cedraro, Emiliano Laudadio, Giulia Sabbatini, Mattia Cantarini, Cristina Minnelli, Giovanna Mobbili, Emanuela Frangipani, Francesca Biavasco, Roberta Galeazzi
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
efflux pump inhibitors
<i>Pseudomonas aeruginosa</i>
berberine derivatives
molecular modeling
multidrug resistance
Organic chemistry
QD241-441
Acceso en línea:https://doaj.org/article/0260bdc7601d46bcb7d1ad71a4ced2cb
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https://doaj.org/article/0260bdc7601d46bcb7d1ad71a4ced2cb

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