CRISPRi-Guided Metabolic Flux Engineering for Enhanced Protopanaxadiol Production in <i>Saccharomyces cerevisiae</i>

CRISPRi-Guided Metabolic Flux Engineering for Enhanced Protopanaxadiol Production in <i>Saccharomyces cerevisiae</i>

Protopanaxadiol (PPD), an aglycon found in several dammarene-type ginsenosides, has high potency as a pharmaceutical. Nevertheless, application of these ginsenosides has been limited because of the high production cost due to the rare content of PPD in <i>Panax ginseng</i> and a long cul...

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Main Authors: Soo-Hwan Lim, Jong-In Baek, Byeong-Min Jeon, Jung-Woo Seo, Min-Sung Kim, Ji-Young Byun, Soo-Hoon Park, Su-Jin Kim, Ju-Young Lee, Jun-Hyoung Lee, Sun-Chang Kim
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
CRISPR interference
lanosterol
protopanaxadiol
triterpenes
metabolic engineering
ginsenosides
Biology (General)
QH301-705.5
Chemistry
QD1-999
Online Access:https://doaj.org/article/02730777a46045f6b9798ef23abf6b1b
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https://doaj.org/article/02730777a46045f6b9798ef23abf6b1b

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