Pichia pastoris-expressed dengue 2 envelope forms virus-like particles without pre-membrane protein and induces high titer neutralizing antibodies.

Dengue is a mosquito-borne viral disease with a global prevalence. It is caused by four closely-related dengue viruses (DENVs 1-4). A dengue vaccine that can protect against all four viruses is an unmet public health need. Live attenuated vaccine development efforts have encountered unexpected inter...

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Autores principales: Shailendra Mani, Lav Tripathi, Rajendra Raut, Poornima Tyagi, Upasana Arora, Tarani Barman, Ruchi Sood, Alka Galav, Wahala Wahala, Aravinda de Silva, Sathyamangalam Swaminathan, Navin Khanna
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/02a210b024a847a7b5bb68d96eb5272e
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