Evolutionary Selection on Barrier Activity: Bar1 Is an Aspartyl Protease with Novel Substrate Specificity

ABSTRACT Peptide-based pheromones are used throughout the fungal kingdom for coordinating sexual responses between mating partners. Here, we address the properties and function of Bar1, an aspartyl protease that acts as a “barrier” and antagonist to pheromone signaling in multiple species. Candida a...

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Bibliographic Details
Main Authors: Stephen K. Jones, Starlynn C. Clarke, Charles S. Craik, Richard J. Bennett
Format: article
Language:EN
Published: American Society for Microbiology 2015
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Online Access:https://doaj.org/article/02af93dcc5074eba9b425b0730e6d660
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