TPH1 and 5-HT<sub>7</sub> Receptor Overexpression Leading to Gemcitabine-Resistance Requires Non-Canonical Permissive Action of EZH2 in Pancreatic Ductal Adenocarcinoma

TPH1 and 5-HT<sub>7</sub> Receptor Overexpression Leading to Gemcitabine-Resistance Requires Non-Canonical Permissive Action of EZH2 in Pancreatic Ductal Adenocarcinoma

In the present study, we investigated the regulatory mechanisms underlying overexpression of EZH2, tryptophan hydroxylase 1 (TPH1), and 5-HT<sub>7</sub>, in relation to gemcitabine resistance and CSC survival in PDAC cells. In aggressive PANC-1 and MIA PaCa-2 cells, knock-down (KD) of EZ...

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Autores principales: Prakash Chaudhary, Diwakar Guragain, Jae-Hoon Chang, Jung-Ae Kim
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
pancreatic ductal adenocarcinoma
gemcitabine-resistance
cancer stem cells
Enhancer of zeste homolog 2
tryptophan hydroxylase 1
5-HT<sub>7</sub>
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/02cdd7aa1b8f41acb4e0f8e272d84f6e
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https://doaj.org/article/02cdd7aa1b8f41acb4e0f8e272d84f6e

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