Excess of mutational jackpot events in expanding populations revealed by spatial Luria–Delbrück experiments

Large mutant clones arising from early mutations in growing cell populations facilitate short-term evolution in microbes and in tumours. Here the authors analyse spatially expanding colonies, and show that large mutant clones can also arise late when they surf at expanding frontiers.

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Autores principales: Diana Fusco, Matti Gralka, Jona Kayser, Alex Anderson, Oskar Hallatschek
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/02d9f95689fa4a2a9130f577bebd8d1e
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