Excess of mutational jackpot events in expanding populations revealed by spatial Luria–Delbrück experiments

Large mutant clones arising from early mutations in growing cell populations facilitate short-term evolution in microbes and in tumours. Here the authors analyse spatially expanding colonies, and show that large mutant clones can also arise late when they surf at expanding frontiers.

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Bibliographic Details
Main Authors:	Diana Fusco, Matti Gralka, Jona Kayser, Alex Anderson, Oskar Hallatschek
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/02d9f95689fa4a2a9130f577bebd8d1e
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spelling	oai:doaj.org-article:02d9f95689fa4a2a9130f577bebd8d1e2021-12-02T17:33:08ZExcess of mutational jackpot events in expanding populations revealed by spatial Luria–Delbrück experiments10.1038/ncomms127602041-1723https://doaj.org/article/02d9f95689fa4a2a9130f577bebd8d1e2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12760https://doaj.org/toc/2041-1723Large mutant clones arising from early mutations in growing cell populations facilitate short-term evolution in microbes and in tumours. Here the authors analyse spatially expanding colonies, and show that large mutant clones can also arise late when they surf at expanding frontiers.Diana FuscoMatti GralkaJona KayserAlex AndersonOskar HallatschekNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Diana Fusco Matti Gralka Jona Kayser Alex Anderson Oskar Hallatschek Excess of mutational jackpot events in expanding populations revealed by spatial Luria–Delbrück experiments
description	Large mutant clones arising from early mutations in growing cell populations facilitate short-term evolution in microbes and in tumours. Here the authors analyse spatially expanding colonies, and show that large mutant clones can also arise late when they surf at expanding frontiers.
format	article
author	Diana Fusco Matti Gralka Jona Kayser Alex Anderson Oskar Hallatschek
author_facet	Diana Fusco Matti Gralka Jona Kayser Alex Anderson Oskar Hallatschek
author_sort	Diana Fusco
title	Excess of mutational jackpot events in expanding populations revealed by spatial Luria–Delbrück experiments
title_short	Excess of mutational jackpot events in expanding populations revealed by spatial Luria–Delbrück experiments
title_full	Excess of mutational jackpot events in expanding populations revealed by spatial Luria–Delbrück experiments
title_fullStr	Excess of mutational jackpot events in expanding populations revealed by spatial Luria–Delbrück experiments
title_full_unstemmed	Excess of mutational jackpot events in expanding populations revealed by spatial Luria–Delbrück experiments
title_sort	excess of mutational jackpot events in expanding populations revealed by spatial luria–delbrück experiments
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/02d9f95689fa4a2a9130f577bebd8d1e
work_keys_str_mv	AT dianafusco excessofmutationaljackpoteventsinexpandingpopulationsrevealedbyspatialluriadelbruckexperiments AT mattigralka excessofmutationaljackpoteventsinexpandingpopulationsrevealedbyspatialluriadelbruckexperiments AT jonakayser excessofmutationaljackpoteventsinexpandingpopulationsrevealedbyspatialluriadelbruckexperiments AT alexanderson excessofmutationaljackpoteventsinexpandingpopulationsrevealedbyspatialluriadelbruckexperiments AT oskarhallatschek excessofmutationaljackpoteventsinexpandingpopulationsrevealedbyspatialluriadelbruckexperiments
_version_	1718380041113436160

Excess of mutational jackpot events in expanding populations revealed by spatial Luria–Delbrück experiments

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