Excess of mutational jackpot events in expanding populations revealed by spatial Luria–Delbrück experiments
Large mutant clones arising from early mutations in growing cell populations facilitate short-term evolution in microbes and in tumours. Here the authors analyse spatially expanding colonies, and show that large mutant clones can also arise late when they surf at expanding frontiers.
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Main Authors: | Diana Fusco, Matti Gralka, Jona Kayser, Alex Anderson, Oskar Hallatschek |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2016
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Online Access: | https://doaj.org/article/02d9f95689fa4a2a9130f577bebd8d1e |
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