Excess of mutational jackpot events in expanding populations revealed by spatial Luria–Delbrück experiments

Large mutant clones arising from early mutations in growing cell populations facilitate short-term evolution in microbes and in tumours. Here the authors analyse spatially expanding colonies, and show that large mutant clones can also arise late when they surf at expanding frontiers.

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Bibliographic Details
Main Authors: Diana Fusco, Matti Gralka, Jona Kayser, Alex Anderson, Oskar Hallatschek
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Q
Online Access:https://doaj.org/article/02d9f95689fa4a2a9130f577bebd8d1e
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