A proline switch explains kinetic heterogeneity in a coupled folding and binding reaction

How intrinsically disordered proteins (IDPs) undergo a coupled folding and binding reaction with their molecular targets remains to be understood. Here authors use single-molecule FRET to assess the contribution of cis/trans isomerization of peptidyl-prolyl bonds in regulating IDP interactions.

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Autores principales: Franziska Zosel, Davide Mercadante, Daniel Nettels, Benjamin Schuler
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/0300d09d545747a38524b19feaddaff8
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