A proline switch explains kinetic heterogeneity in a coupled folding and binding reaction

How intrinsically disordered proteins (IDPs) undergo a coupled folding and binding reaction with their molecular targets remains to be understood. Here authors use single-molecule FRET to assess the contribution of cis/trans isomerization of peptidyl-prolyl bonds in regulating IDP interactions.

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Autores principales:	Franziska Zosel, Davide Mercadante, Daniel Nettels, Benjamin Schuler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0300d09d545747a38524b19feaddaff8
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spelling	oai:doaj.org-article:0300d09d545747a38524b19feaddaff82021-12-02T17:31:12ZA proline switch explains kinetic heterogeneity in a coupled folding and binding reaction10.1038/s41467-018-05725-02041-1723https://doaj.org/article/0300d09d545747a38524b19feaddaff82018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05725-0https://doaj.org/toc/2041-1723How intrinsically disordered proteins (IDPs) undergo a coupled folding and binding reaction with their molecular targets remains to be understood. Here authors use single-molecule FRET to assess the contribution of cis/trans isomerization of peptidyl-prolyl bonds in regulating IDP interactions.Franziska ZoselDavide MercadanteDaniel NettelsBenjamin SchulerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Franziska Zosel Davide Mercadante Daniel Nettels Benjamin Schuler A proline switch explains kinetic heterogeneity in a coupled folding and binding reaction
description	How intrinsically disordered proteins (IDPs) undergo a coupled folding and binding reaction with their molecular targets remains to be understood. Here authors use single-molecule FRET to assess the contribution of cis/trans isomerization of peptidyl-prolyl bonds in regulating IDP interactions.
format	article
author	Franziska Zosel Davide Mercadante Daniel Nettels Benjamin Schuler
author_facet	Franziska Zosel Davide Mercadante Daniel Nettels Benjamin Schuler
author_sort	Franziska Zosel
title	A proline switch explains kinetic heterogeneity in a coupled folding and binding reaction
title_short	A proline switch explains kinetic heterogeneity in a coupled folding and binding reaction
title_full	A proline switch explains kinetic heterogeneity in a coupled folding and binding reaction
title_fullStr	A proline switch explains kinetic heterogeneity in a coupled folding and binding reaction
title_full_unstemmed	A proline switch explains kinetic heterogeneity in a coupled folding and binding reaction
title_sort	proline switch explains kinetic heterogeneity in a coupled folding and binding reaction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0300d09d545747a38524b19feaddaff8
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A proline switch explains kinetic heterogeneity in a coupled folding and binding reaction

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