Mechanical Stretch Induces Annulus Fibrosus Cell Senescence through Activation of the RhoA/ROCK Pathway

Background. Intervertebral disc is responsible for absorbing and transmitting mechanical compression. Under physiological conditions, the peripheral annulus fibrosus (AF) cells are subjected to different magnitudes of transverse mechanical stretch depending on the swelling of the central nucleus pul...

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Bibliographic Details
Main Authors: Li Ning, Lei Gao, Fan Zhang, Xiaoxiao Li, Tingting Wang
Format: article
Language:EN
Published: Hindawi Limited 2021
Subjects:
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Online Access:https://doaj.org/article/030d7908d53c49b295f683041c6a8b73
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