A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links

When DNA interstrand cross-links damage occurs, it causes disruption of replication and transcription. Here the authors identify FAM120B/SAN1, a 5′ exonuclease involved in the repair process of Interstrand Crosslinks independently of the Fanconi Anemia pathway.

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Autores principales: Alex M. Andrews, Heather J. McCartney, Tim M. Errington, Alan D. D’Andrea, Ian G. Macara
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/031ac7b17c8c4e12a4254e48a3e6d6a6
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