Caffeine inhibits hypothalamic A1R to excite oxytocin neuron and ameliorate dietary obesity in mice

The mechanism by which caffeine, an antagonist of adenosine receptors, regulates metabolism is not clear. Here the authors show that adenosine A1R receptor expression is increased in the hypothalamus of diet-induced obesity mice, and that body weight can be alleviated by central administration of ca...

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Autores principales:	Liufeng Wu, Jia Meng, Qing Shen, Yi Zhang, Susu Pan, Zhuo Chen, Ling-Qiang Zhu, Youming Lu, Yuan Huang, Guo Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0330342e5f7e48ee99ed295bb8642fea
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id	oai:doaj.org-article:0330342e5f7e48ee99ed295bb8642fea
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spelling	oai:doaj.org-article:0330342e5f7e48ee99ed295bb8642fea2021-12-02T17:01:18ZCaffeine inhibits hypothalamic A1R to excite oxytocin neuron and ameliorate dietary obesity in mice10.1038/ncomms159042041-1723https://doaj.org/article/0330342e5f7e48ee99ed295bb8642fea2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15904https://doaj.org/toc/2041-1723The mechanism by which caffeine, an antagonist of adenosine receptors, regulates metabolism is not clear. Here the authors show that adenosine A1R receptor expression is increased in the hypothalamus of diet-induced obesity mice, and that body weight can be alleviated by central administration of caffeine via its action on hypothalamic oxytocin neurons.Liufeng WuJia MengQing ShenYi ZhangSusu PanZhuo ChenLing-Qiang ZhuYouming LuYuan HuangGuo ZhangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liufeng Wu Jia Meng Qing Shen Yi Zhang Susu Pan Zhuo Chen Ling-Qiang Zhu Youming Lu Yuan Huang Guo Zhang Caffeine inhibits hypothalamic A1R to excite oxytocin neuron and ameliorate dietary obesity in mice
description	The mechanism by which caffeine, an antagonist of adenosine receptors, regulates metabolism is not clear. Here the authors show that adenosine A1R receptor expression is increased in the hypothalamus of diet-induced obesity mice, and that body weight can be alleviated by central administration of caffeine via its action on hypothalamic oxytocin neurons.
format	article
author	Liufeng Wu Jia Meng Qing Shen Yi Zhang Susu Pan Zhuo Chen Ling-Qiang Zhu Youming Lu Yuan Huang Guo Zhang
author_facet	Liufeng Wu Jia Meng Qing Shen Yi Zhang Susu Pan Zhuo Chen Ling-Qiang Zhu Youming Lu Yuan Huang Guo Zhang
author_sort	Liufeng Wu
title	Caffeine inhibits hypothalamic A1R to excite oxytocin neuron and ameliorate dietary obesity in mice
title_short	Caffeine inhibits hypothalamic A1R to excite oxytocin neuron and ameliorate dietary obesity in mice
title_full	Caffeine inhibits hypothalamic A1R to excite oxytocin neuron and ameliorate dietary obesity in mice
title_fullStr	Caffeine inhibits hypothalamic A1R to excite oxytocin neuron and ameliorate dietary obesity in mice
title_full_unstemmed	Caffeine inhibits hypothalamic A1R to excite oxytocin neuron and ameliorate dietary obesity in mice
title_sort	caffeine inhibits hypothalamic a1r to excite oxytocin neuron and ameliorate dietary obesity in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0330342e5f7e48ee99ed295bb8642fea
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Caffeine inhibits hypothalamic A1R to excite oxytocin neuron and ameliorate dietary obesity in mice

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