Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel

Summary: Transient receptor potential melastatin 2 (TRPM2), a Ca2+-permeable cation channel, is gated by intracellular adenosine diphosphate ribose (ADPR), Ca2+, warm temperature, and oxidative stress. It is critically involved in physiological and pathological processes ranging from inflammation to...

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Autores principales: Xiafei Yu, Yuan Xie, Xiaokang Zhang, Cheng Ma, Likun Liu, Wenxuan Zhen, Lingyi Xu, Jianmin Zhang, Yan Liang, Lixia Zhao, Xiuxia Gao, Peilin Yu, Jianhong Luo, Lin-Hua Jiang, Yan Nie, Fan Yang, Jiangtao Guo, Wei Yang
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/033b93d8d1d24aa1ad3a824d21df3eb9
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