Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel

Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel

Summary: Transient receptor potential melastatin 2 (TRPM2), a Ca2+-permeable cation channel, is gated by intracellular adenosine diphosphate ribose (ADPR), Ca2+, warm temperature, and oxidative stress. It is critically involved in physiological and pathological processes ranging from inflammation to...

Full description

Saved in:
Bibliographic Details
Main Authors: Xiafei Yu, Yuan Xie, Xiaokang Zhang, Cheng Ma, Likun Liu, Wenxuan Zhen, Lingyi Xu, Jianmin Zhang, Yan Liang, Lixia Zhao, Xiuxia Gao, Peilin Yu, Jianhong Luo, Lin-Hua Jiang, Yan Nie, Fan Yang, Jiangtao Guo, Wei Yang
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
structure of TRPM2 channel
selectivity filter
Ag+ modification
computational modeling
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/033b93d8d1d24aa1ad3a824d21df3eb9
Tags: Add Tag
No Tags, Be the first to tag this record!
Be the first to leave a comment!
You must be logged in first

Similar Items