Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel

Summary: Transient receptor potential melastatin 2 (TRPM2), a Ca2+-permeable cation channel, is gated by intracellular adenosine diphosphate ribose (ADPR), Ca2+, warm temperature, and oxidative stress. It is critically involved in physiological and pathological processes ranging from inflammation to...

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Auteurs principaux:	Xiafei Yu, Yuan Xie, Xiaokang Zhang, Cheng Ma, Likun Liu, Wenxuan Zhen, Lingyi Xu, Jianmin Zhang, Yan Liang, Lixia Zhao, Xiuxia Gao, Peilin Yu, Jianhong Luo, Lin-Hua Jiang, Yan Nie, Fan Yang, Jiangtao Guo, Wei Yang
Format:	article
Langue:	EN
Publié:	Elsevier 2021
Sujets:	structure of TRPM2 channel selectivity filter Ag+ modification computational modeling Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/033b93d8d1d24aa1ad3a824d21df3eb9
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Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel

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