Supramolecular trap for catching polyamines in cells as an anti-tumor strategy

Polyamines are essential for cell growth and are frequently increased in concentration in cancer cells. Here, the authors use a macrocycle to generate a supramolecular trap, which depletes the polyamines in cells, induces apoptosis and reduces cancer cell growth in mice.

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Autores principales:	Junyi Chen, Hanzhi Ni, Zhao Meng, Jing Wang, Xiayang Huang, Yansheng Dong, Chao Sun, Yadan Zhang, Lei Cui, Jian Li, Xueshun Jia, Qingbin Meng, Chunju Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/036605c0fa524d228d5ca0375dc359af
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spelling	oai:doaj.org-article:036605c0fa524d228d5ca0375dc359af2021-12-02T17:01:45ZSupramolecular trap for catching polyamines in cells as an anti-tumor strategy10.1038/s41467-019-11553-72041-1723https://doaj.org/article/036605c0fa524d228d5ca0375dc359af2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11553-7https://doaj.org/toc/2041-1723Polyamines are essential for cell growth and are frequently increased in concentration in cancer cells. Here, the authors use a macrocycle to generate a supramolecular trap, which depletes the polyamines in cells, induces apoptosis and reduces cancer cell growth in mice.Junyi ChenHanzhi NiZhao MengJing WangXiayang HuangYansheng DongChao SunYadan ZhangLei CuiJian LiXueshun JiaQingbin MengChunju LiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Junyi Chen Hanzhi Ni Zhao Meng Jing Wang Xiayang Huang Yansheng Dong Chao Sun Yadan Zhang Lei Cui Jian Li Xueshun Jia Qingbin Meng Chunju Li Supramolecular trap for catching polyamines in cells as an anti-tumor strategy
description	Polyamines are essential for cell growth and are frequently increased in concentration in cancer cells. Here, the authors use a macrocycle to generate a supramolecular trap, which depletes the polyamines in cells, induces apoptosis and reduces cancer cell growth in mice.
format	article
author	Junyi Chen Hanzhi Ni Zhao Meng Jing Wang Xiayang Huang Yansheng Dong Chao Sun Yadan Zhang Lei Cui Jian Li Xueshun Jia Qingbin Meng Chunju Li
author_facet	Junyi Chen Hanzhi Ni Zhao Meng Jing Wang Xiayang Huang Yansheng Dong Chao Sun Yadan Zhang Lei Cui Jian Li Xueshun Jia Qingbin Meng Chunju Li
author_sort	Junyi Chen
title	Supramolecular trap for catching polyamines in cells as an anti-tumor strategy
title_short	Supramolecular trap for catching polyamines in cells as an anti-tumor strategy
title_full	Supramolecular trap for catching polyamines in cells as an anti-tumor strategy
title_fullStr	Supramolecular trap for catching polyamines in cells as an anti-tumor strategy
title_full_unstemmed	Supramolecular trap for catching polyamines in cells as an anti-tumor strategy
title_sort	supramolecular trap for catching polyamines in cells as an anti-tumor strategy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/036605c0fa524d228d5ca0375dc359af
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Supramolecular trap for catching polyamines in cells as an anti-tumor strategy

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