CRISPR Interference of a Clonally Variant GC-Rich Noncoding RNA Family Leads to General Repression of <italic toggle="yes">var</italic> Genes in <named-content content-type="genus-species">Plasmodium falciparum</named-content>

CRISPR Interference of a Clonally Variant GC-Rich Noncoding RNA Family Leads to General Repression of <italic toggle="yes">var</italic> Genes in <named-content content-type="genus-species">Plasmodium falciparum</named-content>

ABSTRACT The human malaria parasite Plasmodium falciparum uses mutually exclusive expression of the PfEMP1-encoding var gene family to evade the host immune system. Despite progress in the molecular understanding of the default silencing mechanism, the activation mechanism of the uniquely expressed...

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Autores principales: Anna Barcons-Simon, Carlos Cordon-Obras, Julien Guizetti, Jessica M. Bryant, Artur Scherf
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
ncRNA
Plasmodium falciparum
antigenic variation
mutually exclusive expression
epigenetics
var genes
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/03d722d0147f412f860ff784e5a0530e
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