CRISPR Interference of a Clonally Variant GC-Rich Noncoding RNA Family Leads to General Repression of <italic toggle="yes">var</italic> Genes in <named-content content-type="genus-species">Plasmodium falciparum</named-content>
ABSTRACT The human malaria parasite Plasmodium falciparum uses mutually exclusive expression of the PfEMP1-encoding var gene family to evade the host immune system. Despite progress in the molecular understanding of the default silencing mechanism, the activation mechanism of the uniquely expressed...
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| Main Authors: | , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
American Society for Microbiology
2020
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| Subjects: | |
| Online Access: | https://doaj.org/article/03d722d0147f412f860ff784e5a0530e |
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