Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity

Broadly neutralizing antibodies targeting HIV Env could potentially be utilized as therapeutics. Here, Steinhardt et al. engineer a trispecific antibody with specificity for the receptor-binding site, a conserved Env glycan patch and the Env membrane proximal region with nearly pan-isolate neutraliz...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	James J. Steinhardt, Javier Guenaga, Hannah L. Turner, Krisha McKee, Mark K. Louder, Sijy O’Dell, Chi-I Chiang, Lin Lei, Andrey Galkin, Alexander K. Andrianov, Nicole A. Doria-Rose, Robert T. Bailer, Andrew B. Ward, John R. Mascola, Yuxing Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/03eaed1d2e664ef483d4e8852e3946e7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:03eaed1d2e664ef483d4e8852e3946e7
record_format	dspace
spelling	oai:doaj.org-article:03eaed1d2e664ef483d4e8852e3946e72021-12-02T16:56:37ZRational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity10.1038/s41467-018-03335-42041-1723https://doaj.org/article/03eaed1d2e664ef483d4e8852e3946e72018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03335-4https://doaj.org/toc/2041-1723Broadly neutralizing antibodies targeting HIV Env could potentially be utilized as therapeutics. Here, Steinhardt et al. engineer a trispecific antibody with specificity for the receptor-binding site, a conserved Env glycan patch and the Env membrane proximal region with nearly pan-isolate neutralization breadth and high potency.James J. SteinhardtJavier GuenagaHannah L. TurnerKrisha McKeeMark K. LouderSijy O’DellChi-I ChiangLin LeiAndrey GalkinAlexander K. AndrianovNicole A. Doria-RoseRobert T. BailerAndrew B. WardJohn R. MascolaYuxing LiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q James J. Steinhardt Javier Guenaga Hannah L. Turner Krisha McKee Mark K. Louder Sijy O’Dell Chi-I Chiang Lin Lei Andrey Galkin Alexander K. Andrianov Nicole A. Doria-Rose Robert T. Bailer Andrew B. Ward John R. Mascola Yuxing Li Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity
description	Broadly neutralizing antibodies targeting HIV Env could potentially be utilized as therapeutics. Here, Steinhardt et al. engineer a trispecific antibody with specificity for the receptor-binding site, a conserved Env glycan patch and the Env membrane proximal region with nearly pan-isolate neutralization breadth and high potency.
format	article
author	James J. Steinhardt Javier Guenaga Hannah L. Turner Krisha McKee Mark K. Louder Sijy O’Dell Chi-I Chiang Lin Lei Andrey Galkin Alexander K. Andrianov Nicole A. Doria-Rose Robert T. Bailer Andrew B. Ward John R. Mascola Yuxing Li
author_facet	James J. Steinhardt Javier Guenaga Hannah L. Turner Krisha McKee Mark K. Louder Sijy O’Dell Chi-I Chiang Lin Lei Andrey Galkin Alexander K. Andrianov Nicole A. Doria-Rose Robert T. Bailer Andrew B. Ward John R. Mascola Yuxing Li
author_sort	James J. Steinhardt
title	Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity
title_short	Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity
title_full	Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity
title_fullStr	Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity
title_full_unstemmed	Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity
title_sort	rational design of a trispecific antibody targeting the hiv-1 env with elevated anti-viral activity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/03eaed1d2e664ef483d4e8852e3946e7
work_keys_str_mv	AT jamesjsteinhardt rationaldesignofatrispecificantibodytargetingthehiv1envwithelevatedantiviralactivity AT javierguenaga rationaldesignofatrispecificantibodytargetingthehiv1envwithelevatedantiviralactivity AT hannahlturner rationaldesignofatrispecificantibodytargetingthehiv1envwithelevatedantiviralactivity AT krishamckee rationaldesignofatrispecificantibodytargetingthehiv1envwithelevatedantiviralactivity AT markklouder rationaldesignofatrispecificantibodytargetingthehiv1envwithelevatedantiviralactivity AT sijyodell rationaldesignofatrispecificantibodytargetingthehiv1envwithelevatedantiviralactivity AT chiichiang rationaldesignofatrispecificantibodytargetingthehiv1envwithelevatedantiviralactivity AT linlei rationaldesignofatrispecificantibodytargetingthehiv1envwithelevatedantiviralactivity AT andreygalkin rationaldesignofatrispecificantibodytargetingthehiv1envwithelevatedantiviralactivity AT alexanderkandrianov rationaldesignofatrispecificantibodytargetingthehiv1envwithelevatedantiviralactivity AT nicoleadoriarose rationaldesignofatrispecificantibodytargetingthehiv1envwithelevatedantiviralactivity AT roberttbailer rationaldesignofatrispecificantibodytargetingthehiv1envwithelevatedantiviralactivity AT andrewbward rationaldesignofatrispecificantibodytargetingthehiv1envwithelevatedantiviralactivity AT johnrmascola rationaldesignofatrispecificantibodytargetingthehiv1envwithelevatedantiviralactivity AT yuxingli rationaldesignofatrispecificantibodytargetingthehiv1envwithelevatedantiviralactivity
_version_	1718382779734949888

Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity

Ejemplares similares