A role for annexin A2 in scaffolding the peroxiredoxin 2–STAT3 redox relay complex

Peroxiredoxin 2 (Prx2) was previously shown to transfer H2O2-derived oxidative equivalents to STAT3, generating disulfide-linked dimers and tetramers. Here the authors show that the interaction between Prx2 and STAT3 at the plasma membrane is mediated by the membrane chaperone annexin A2; suggesting...

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Autores principales:	Deepti Talwar, Joris Messens, Tobias P. Dick
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0437c00ea49c4b13ae922c900e305b00
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spelling	oai:doaj.org-article:0437c00ea49c4b13ae922c900e305b002021-12-02T19:12:28ZA role for annexin A2 in scaffolding the peroxiredoxin 2–STAT3 redox relay complex10.1038/s41467-020-18324-92041-1723https://doaj.org/article/0437c00ea49c4b13ae922c900e305b002020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18324-9https://doaj.org/toc/2041-1723Peroxiredoxin 2 (Prx2) was previously shown to transfer H2O2-derived oxidative equivalents to STAT3, generating disulfide-linked dimers and tetramers. Here the authors show that the interaction between Prx2 and STAT3 at the plasma membrane is mediated by the membrane chaperone annexin A2; suggesting that the redox relay complex is part of a membrane signaling domain.Deepti TalwarJoris MessensTobias P. DickNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Deepti Talwar Joris Messens Tobias P. Dick A role for annexin A2 in scaffolding the peroxiredoxin 2–STAT3 redox relay complex
description	Peroxiredoxin 2 (Prx2) was previously shown to transfer H2O2-derived oxidative equivalents to STAT3, generating disulfide-linked dimers and tetramers. Here the authors show that the interaction between Prx2 and STAT3 at the plasma membrane is mediated by the membrane chaperone annexin A2; suggesting that the redox relay complex is part of a membrane signaling domain.
format	article
author	Deepti Talwar Joris Messens Tobias P. Dick
author_facet	Deepti Talwar Joris Messens Tobias P. Dick
author_sort	Deepti Talwar
title	A role for annexin A2 in scaffolding the peroxiredoxin 2–STAT3 redox relay complex
title_short	A role for annexin A2 in scaffolding the peroxiredoxin 2–STAT3 redox relay complex
title_full	A role for annexin A2 in scaffolding the peroxiredoxin 2–STAT3 redox relay complex
title_fullStr	A role for annexin A2 in scaffolding the peroxiredoxin 2–STAT3 redox relay complex
title_full_unstemmed	A role for annexin A2 in scaffolding the peroxiredoxin 2–STAT3 redox relay complex
title_sort	role for annexin a2 in scaffolding the peroxiredoxin 2–stat3 redox relay complex
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0437c00ea49c4b13ae922c900e305b00
work_keys_str_mv	AT deeptitalwar aroleforannexina2inscaffoldingtheperoxiredoxin2stat3redoxrelaycomplex AT jorismessens aroleforannexina2inscaffoldingtheperoxiredoxin2stat3redoxrelaycomplex AT tobiaspdick aroleforannexina2inscaffoldingtheperoxiredoxin2stat3redoxrelaycomplex AT deeptitalwar roleforannexina2inscaffoldingtheperoxiredoxin2stat3redoxrelaycomplex AT jorismessens roleforannexina2inscaffoldingtheperoxiredoxin2stat3redoxrelaycomplex AT tobiaspdick roleforannexina2inscaffoldingtheperoxiredoxin2stat3redoxrelaycomplex
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A role for annexin A2 in scaffolding the peroxiredoxin 2–STAT3 redox relay complex

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