Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer

Neuroendocrine carcinomas (NECs) arise from different anatomic sites, but have similar histological and clinical features. Here, the authors show that the epigenetic landscape of a range of NECs converges towards a common epigenetic state, while distinct subtypes occur within neuroendocrine prostate...

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Autores principales:	Paloma Cejas, Yingtian Xie, Alba Font-Tello, Klothilda Lim, Sudeepa Syamala, Xintao Qiu, Alok K. Tewari, Neel Shah, Holly M. Nguyen, Radhika A. Patel, Lisha Brown, Ilsa Coleman, Wenzel M. Hackeng, Lodewijk Brosens, Koen M. A. Dreijerink, Leigh Ellis, Sarah Abou Alaiwi, Ji-Heui Seo, Sylvan Baca, Himisha Beltran, Francesca Khani, Mark Pomerantz, Alessandra Dall’Agnese, Jett Crowdis, Eliezer M. Van Allen, Joaquim Bellmunt, Colm Morrisey, Peter S. Nelson, James DeCaprio, Anna Farago, Nicholas Dyson, Benjamin Drapkin, X. Shirley Liu, Matthew Freedman, Michael C. Haffner, Eva Corey, Myles Brown, Henry W. Long
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/049dc4c6a6fd4e8a9fc4ad8f4f885b4e
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spelling	oai:doaj.org-article:049dc4c6a6fd4e8a9fc4ad8f4f885b4e2021-12-02T18:51:36ZSubtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer10.1038/s41467-021-26042-z2041-1723https://doaj.org/article/049dc4c6a6fd4e8a9fc4ad8f4f885b4e2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26042-zhttps://doaj.org/toc/2041-1723Neuroendocrine carcinomas (NECs) arise from different anatomic sites, but have similar histological and clinical features. Here, the authors show that the epigenetic landscape of a range of NECs converges towards a common epigenetic state, while distinct subtypes occur within neuroendocrine prostate cancer contributing to intratumor heterogeneity in clinical samples.Paloma CejasYingtian XieAlba Font-TelloKlothilda LimSudeepa SyamalaXintao QiuAlok K. TewariNeel ShahHolly M. NguyenRadhika A. PatelLisha BrownIlsa ColemanWenzel M. HackengLodewijk BrosensKoen M. A. DreijerinkLeigh EllisSarah Abou AlaiwiJi-Heui SeoSylvan BacaHimisha BeltranFrancesca KhaniMark PomerantzAlessandra Dall’AgneseJett CrowdisEliezer M. Van AllenJoaquim BellmuntColm MorriseyPeter S. NelsonJames DeCaprioAnna FaragoNicholas DysonBenjamin DrapkinX. Shirley LiuMatthew FreedmanMichael C. HaffnerEva CoreyMyles BrownHenry W. LongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paloma Cejas Yingtian Xie Alba Font-Tello Klothilda Lim Sudeepa Syamala Xintao Qiu Alok K. Tewari Neel Shah Holly M. Nguyen Radhika A. Patel Lisha Brown Ilsa Coleman Wenzel M. Hackeng Lodewijk Brosens Koen M. A. Dreijerink Leigh Ellis Sarah Abou Alaiwi Ji-Heui Seo Sylvan Baca Himisha Beltran Francesca Khani Mark Pomerantz Alessandra Dall’Agnese Jett Crowdis Eliezer M. Van Allen Joaquim Bellmunt Colm Morrisey Peter S. Nelson James DeCaprio Anna Farago Nicholas Dyson Benjamin Drapkin X. Shirley Liu Matthew Freedman Michael C. Haffner Eva Corey Myles Brown Henry W. Long Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer
description	Neuroendocrine carcinomas (NECs) arise from different anatomic sites, but have similar histological and clinical features. Here, the authors show that the epigenetic landscape of a range of NECs converges towards a common epigenetic state, while distinct subtypes occur within neuroendocrine prostate cancer contributing to intratumor heterogeneity in clinical samples.
format	article
author	Paloma Cejas Yingtian Xie Alba Font-Tello Klothilda Lim Sudeepa Syamala Xintao Qiu Alok K. Tewari Neel Shah Holly M. Nguyen Radhika A. Patel Lisha Brown Ilsa Coleman Wenzel M. Hackeng Lodewijk Brosens Koen M. A. Dreijerink Leigh Ellis Sarah Abou Alaiwi Ji-Heui Seo Sylvan Baca Himisha Beltran Francesca Khani Mark Pomerantz Alessandra Dall’Agnese Jett Crowdis Eliezer M. Van Allen Joaquim Bellmunt Colm Morrisey Peter S. Nelson James DeCaprio Anna Farago Nicholas Dyson Benjamin Drapkin X. Shirley Liu Matthew Freedman Michael C. Haffner Eva Corey Myles Brown Henry W. Long
author_facet	Paloma Cejas Yingtian Xie Alba Font-Tello Klothilda Lim Sudeepa Syamala Xintao Qiu Alok K. Tewari Neel Shah Holly M. Nguyen Radhika A. Patel Lisha Brown Ilsa Coleman Wenzel M. Hackeng Lodewijk Brosens Koen M. A. Dreijerink Leigh Ellis Sarah Abou Alaiwi Ji-Heui Seo Sylvan Baca Himisha Beltran Francesca Khani Mark Pomerantz Alessandra Dall’Agnese Jett Crowdis Eliezer M. Van Allen Joaquim Bellmunt Colm Morrisey Peter S. Nelson James DeCaprio Anna Farago Nicholas Dyson Benjamin Drapkin X. Shirley Liu Matthew Freedman Michael C. Haffner Eva Corey Myles Brown Henry W. Long
author_sort	Paloma Cejas
title	Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer
title_short	Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer
title_full	Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer
title_fullStr	Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer
title_full_unstemmed	Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer
title_sort	subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/049dc4c6a6fd4e8a9fc4ad8f4f885b4e
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Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer

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