MAIT cells protect against pulmonary Legionella longbeachae infection

Mucosal associated invariant T (MAIT) cells have been implicated in antibacterial responses. Here the authors show MAIT cells confer IFN-γ-mediated protection from lethal infection in a mouse model of Legionella infection, which can be enhanced by synthetic MR1 ligands.

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Autores principales:	Huimeng Wang, Criselle D’Souza, Xin Yi Lim, Lyudmila Kostenko, Troi J. Pediongco, Sidonia B. G. Eckle, Bronwyn S. Meehan, Mai Shi, Nancy Wang, Shihan Li, Ligong Liu, Jeffrey Y. W. Mak, David P. Fairlie, Yoichiro Iwakura, Jennifer M. Gunnersen, Andrew W. Stent, Dale I. Godfrey, Jamie Rossjohn, Glen P. Westall, Lars Kjer-Nielsen, Richard A. Strugnell, James McCluskey, Alexandra J. Corbett, Timothy S. C. Hinks, Zhenjun Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/04a7234e223649d8b39e28253a1e7287
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spelling	oai:doaj.org-article:04a7234e223649d8b39e28253a1e72872021-12-02T17:32:32ZMAIT cells protect against pulmonary Legionella longbeachae infection10.1038/s41467-018-05202-82041-1723https://doaj.org/article/04a7234e223649d8b39e28253a1e72872018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05202-8https://doaj.org/toc/2041-1723Mucosal associated invariant T (MAIT) cells have been implicated in antibacterial responses. Here the authors show MAIT cells confer IFN-γ-mediated protection from lethal infection in a mouse model of Legionella infection, which can be enhanced by synthetic MR1 ligands.Huimeng WangCriselle D’SouzaXin Yi LimLyudmila KostenkoTroi J. PediongcoSidonia B. G. EckleBronwyn S. MeehanMai ShiNancy WangShihan LiLigong LiuJeffrey Y. W. MakDavid P. FairlieYoichiro IwakuraJennifer M. GunnersenAndrew W. StentDale I. GodfreyJamie RossjohnGlen P. WestallLars Kjer-NielsenRichard A. StrugnellJames McCluskeyAlexandra J. CorbettTimothy S. C. HinksZhenjun ChenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huimeng Wang Criselle D’Souza Xin Yi Lim Lyudmila Kostenko Troi J. Pediongco Sidonia B. G. Eckle Bronwyn S. Meehan Mai Shi Nancy Wang Shihan Li Ligong Liu Jeffrey Y. W. Mak David P. Fairlie Yoichiro Iwakura Jennifer M. Gunnersen Andrew W. Stent Dale I. Godfrey Jamie Rossjohn Glen P. Westall Lars Kjer-Nielsen Richard A. Strugnell James McCluskey Alexandra J. Corbett Timothy S. C. Hinks Zhenjun Chen MAIT cells protect against pulmonary Legionella longbeachae infection
description	Mucosal associated invariant T (MAIT) cells have been implicated in antibacterial responses. Here the authors show MAIT cells confer IFN-γ-mediated protection from lethal infection in a mouse model of Legionella infection, which can be enhanced by synthetic MR1 ligands.
format	article
author	Huimeng Wang Criselle D’Souza Xin Yi Lim Lyudmila Kostenko Troi J. Pediongco Sidonia B. G. Eckle Bronwyn S. Meehan Mai Shi Nancy Wang Shihan Li Ligong Liu Jeffrey Y. W. Mak David P. Fairlie Yoichiro Iwakura Jennifer M. Gunnersen Andrew W. Stent Dale I. Godfrey Jamie Rossjohn Glen P. Westall Lars Kjer-Nielsen Richard A. Strugnell James McCluskey Alexandra J. Corbett Timothy S. C. Hinks Zhenjun Chen
author_facet	Huimeng Wang Criselle D’Souza Xin Yi Lim Lyudmila Kostenko Troi J. Pediongco Sidonia B. G. Eckle Bronwyn S. Meehan Mai Shi Nancy Wang Shihan Li Ligong Liu Jeffrey Y. W. Mak David P. Fairlie Yoichiro Iwakura Jennifer M. Gunnersen Andrew W. Stent Dale I. Godfrey Jamie Rossjohn Glen P. Westall Lars Kjer-Nielsen Richard A. Strugnell James McCluskey Alexandra J. Corbett Timothy S. C. Hinks Zhenjun Chen
author_sort	Huimeng Wang
title	MAIT cells protect against pulmonary Legionella longbeachae infection
title_short	MAIT cells protect against pulmonary Legionella longbeachae infection
title_full	MAIT cells protect against pulmonary Legionella longbeachae infection
title_fullStr	MAIT cells protect against pulmonary Legionella longbeachae infection
title_full_unstemmed	MAIT cells protect against pulmonary Legionella longbeachae infection
title_sort	mait cells protect against pulmonary legionella longbeachae infection
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/04a7234e223649d8b39e28253a1e7287
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MAIT cells protect against pulmonary Legionella longbeachae infection

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