Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment

During meiosis, chromosomes undergo dramatic changes in morphology and intranuclear positioning. Here the authors mapped the 3D genome architecture throughout mouse spermatogenesis by Hi-C of sorted cells to reveal the contributions of transcriptional activity and mechanical force in modulating homo...

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Autores principales:	Wu Zuo, Guangming Chen, Zhimei Gao, Shuai Li, Yanyan Chen, Chenhui Huang, Juan Chen, Zhengjun Chen, Ming Lei, Qian Bian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/04bab0aa74074e349ddf98974f462098
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spelling	oai:doaj.org-article:04bab0aa74074e349ddf98974f4620982021-12-02T18:01:42ZStage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment10.1038/s41467-021-26033-02041-1723https://doaj.org/article/04bab0aa74074e349ddf98974f4620982021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26033-0https://doaj.org/toc/2041-1723During meiosis, chromosomes undergo dramatic changes in morphology and intranuclear positioning. Here the authors mapped the 3D genome architecture throughout mouse spermatogenesis by Hi-C of sorted cells to reveal the contributions of transcriptional activity and mechanical force in modulating homolog alignment and recombination.Wu ZuoGuangming ChenZhimei GaoShuai LiYanyan ChenChenhui HuangJuan ChenZhengjun ChenMing LeiQian BianNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wu Zuo Guangming Chen Zhimei Gao Shuai Li Yanyan Chen Chenhui Huang Juan Chen Zhengjun Chen Ming Lei Qian Bian Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment
description	During meiosis, chromosomes undergo dramatic changes in morphology and intranuclear positioning. Here the authors mapped the 3D genome architecture throughout mouse spermatogenesis by Hi-C of sorted cells to reveal the contributions of transcriptional activity and mechanical force in modulating homolog alignment and recombination.
format	article
author	Wu Zuo Guangming Chen Zhimei Gao Shuai Li Yanyan Chen Chenhui Huang Juan Chen Zhengjun Chen Ming Lei Qian Bian
author_facet	Wu Zuo Guangming Chen Zhimei Gao Shuai Li Yanyan Chen Chenhui Huang Juan Chen Zhengjun Chen Ming Lei Qian Bian
author_sort	Wu Zuo
title	Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment
title_short	Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment
title_full	Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment
title_fullStr	Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment
title_full_unstemmed	Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment
title_sort	stage-resolved hi-c analyses reveal meiotic chromosome organizational features influencing homolog alignment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/04bab0aa74074e349ddf98974f462098
work_keys_str_mv	AT wuzuo stageresolvedhicanalysesrevealmeioticchromosomeorganizationalfeaturesinfluencinghomologalignment AT guangmingchen stageresolvedhicanalysesrevealmeioticchromosomeorganizationalfeaturesinfluencinghomologalignment AT zhimeigao stageresolvedhicanalysesrevealmeioticchromosomeorganizationalfeaturesinfluencinghomologalignment AT shuaili stageresolvedhicanalysesrevealmeioticchromosomeorganizationalfeaturesinfluencinghomologalignment AT yanyanchen stageresolvedhicanalysesrevealmeioticchromosomeorganizationalfeaturesinfluencinghomologalignment AT chenhuihuang stageresolvedhicanalysesrevealmeioticchromosomeorganizationalfeaturesinfluencinghomologalignment AT juanchen stageresolvedhicanalysesrevealmeioticchromosomeorganizationalfeaturesinfluencinghomologalignment AT zhengjunchen stageresolvedhicanalysesrevealmeioticchromosomeorganizationalfeaturesinfluencinghomologalignment AT minglei stageresolvedhicanalysesrevealmeioticchromosomeorganizationalfeaturesinfluencinghomologalignment AT qianbian stageresolvedhicanalysesrevealmeioticchromosomeorganizationalfeaturesinfluencinghomologalignment
_version_	1718378908281208832

Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment

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