Molecular basis of human CD22 function and therapeutic targeting

The B-cell-specific co-receptor CD22 is a therapeutic target for depleting dysregulated B cells. Here the authors structurally characterize the ectodomain of CD22 and present its crystal structure with the bound therapeutic antibody epratuzumab, which gives insights into the mechanism of inhibition...

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Autores principales:	June Ereño-Orbea, Taylor Sicard, Hong Cui, Mohammad T. Mazhab-Jafari, Samir Benlekbir, Alba Guarné, John L. Rubinstein, Jean-Philippe Julien
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/04e84326931749769862d90cdc858a46
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spelling	oai:doaj.org-article:04e84326931749769862d90cdc858a462021-12-02T15:38:37ZMolecular basis of human CD22 function and therapeutic targeting10.1038/s41467-017-00836-62041-1723https://doaj.org/article/04e84326931749769862d90cdc858a462017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00836-6https://doaj.org/toc/2041-1723The B-cell-specific co-receptor CD22 is a therapeutic target for depleting dysregulated B cells. Here the authors structurally characterize the ectodomain of CD22 and present its crystal structure with the bound therapeutic antibody epratuzumab, which gives insights into the mechanism of inhibition of B-cell activation.June Ereño-OrbeaTaylor SicardHong CuiMohammad T. Mazhab-JafariSamir BenlekbirAlba GuarnéJohn L. RubinsteinJean-Philippe JulienNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q June Ereño-Orbea Taylor Sicard Hong Cui Mohammad T. Mazhab-Jafari Samir Benlekbir Alba Guarné John L. Rubinstein Jean-Philippe Julien Molecular basis of human CD22 function and therapeutic targeting
description	The B-cell-specific co-receptor CD22 is a therapeutic target for depleting dysregulated B cells. Here the authors structurally characterize the ectodomain of CD22 and present its crystal structure with the bound therapeutic antibody epratuzumab, which gives insights into the mechanism of inhibition of B-cell activation.
format	article
author	June Ereño-Orbea Taylor Sicard Hong Cui Mohammad T. Mazhab-Jafari Samir Benlekbir Alba Guarné John L. Rubinstein Jean-Philippe Julien
author_facet	June Ereño-Orbea Taylor Sicard Hong Cui Mohammad T. Mazhab-Jafari Samir Benlekbir Alba Guarné John L. Rubinstein Jean-Philippe Julien
author_sort	June Ereño-Orbea
title	Molecular basis of human CD22 function and therapeutic targeting
title_short	Molecular basis of human CD22 function and therapeutic targeting
title_full	Molecular basis of human CD22 function and therapeutic targeting
title_fullStr	Molecular basis of human CD22 function and therapeutic targeting
title_full_unstemmed	Molecular basis of human CD22 function and therapeutic targeting
title_sort	molecular basis of human cd22 function and therapeutic targeting
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/04e84326931749769862d90cdc858a46
work_keys_str_mv	AT juneerenoorbea molecularbasisofhumancd22functionandtherapeutictargeting AT taylorsicard molecularbasisofhumancd22functionandtherapeutictargeting AT hongcui molecularbasisofhumancd22functionandtherapeutictargeting AT mohammadtmazhabjafari molecularbasisofhumancd22functionandtherapeutictargeting AT samirbenlekbir molecularbasisofhumancd22functionandtherapeutictargeting AT albaguarne molecularbasisofhumancd22functionandtherapeutictargeting AT johnlrubinstein molecularbasisofhumancd22functionandtherapeutictargeting AT jeanphilippejulien molecularbasisofhumancd22functionandtherapeutictargeting
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Molecular basis of human CD22 function and therapeutic targeting

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