Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies

por Edurne Rujas, Hong Cui, Taylor Sicard, Anthony Semesi, Jean-Philippe Julien
Publicado 2020

Molecular basis of human CD22 function and therapeutic targeting

por June Ereño-Orbea, Taylor Sicard, Hong Cui, Mohammad T. Mazhab-Jafari, Samir Benlekbir, Alba Guarné, John L. Rubinstein, Jean-Philippe Julien
Publicado 2017

Molecular recognition of the native HIV-1 MPER revealed by STED microscopy of single virions

por Pablo Carravilla, Jakub Chojnacki, Edurne Rujas, Sara Insausti, Eneko Largo, Dominic Waithe, Beatriz Apellaniz, Taylor Sicard, Jean-Philippe Julien, Christian Eggeling, José L. Nieva
Publicado 2019

Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45

por Prasun Kundu, Anthony Semesi, Matthijs M. Jore, Merribeth J. Morin, Virginia L. Price, Alice Liang, Jingxing Li, Kazutoyo Miura, Robert W. Sauerwein, C. Richter King, Jean-Philippe Julien
Publicado 2018

Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25

por Brandon McLeod, Kazutoyo Miura, Stephen W. Scally, Alexandre Bosch, Ngan Nguyen, Hanjun Shin, Dongkyoon Kim, Wayne Volkmuth, Sebastian Rämisch, Jessica A. Chichester, Stephen Streatfield, Colleen Woods, William R. Schief, Daniel Emerling, C. Richter King, Jean-Philippe Julien
Publicado 2019

Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25

por Stephen W. Scally, Brandon McLeod, Alexandre Bosch, Kazutoyo Miura, Qi Liang, Sean Carroll, Sini Reponen, Ngan Nguyen, Eldar Giladi, Sebastian Rämisch, Vidadi Yusibov, Allan Bradley, Franck Lemiale, William R. Schief, Daniel Emerling, Paul Kellam, C. Richter King, Jean-Philippe Julien
Publicado 2017

A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands

por Emily Rodrigues, Jaesoo Jung, Heajin Park, Caleb Loo, Sepideh Soukhtehzari, Elena N. Kitova, Fahima Mozaneh, Gour Daskhan, Edward N. Schmidt, Vivian Aghanya, Susmita Sarkar, Laura Streith, Chris D. St. Laurent, Linh Nguyen, Jean-Philippe Julien, Lori J. West, Karla C. Williams, John S. Klassen, Matthew S. Macauley
Publicado 2020

A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies.

por Rogier W Sanders, Ronald Derking, Albert Cupo, Jean-Philippe Julien, Anila Yasmeen, Natalia de Val, Helen J Kim, Claudia Blattner, Alba Torrents de la Peña, Jacob Korzun, Michael Golabek, Kevin de Los Reyes, Thomas J Ketas, Marit J van Gils, C Richter King, Ian A Wilson, Andrew B Ward, P J Klasse, John P Moore
Publicado 2013

Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease

por Michael G. Sugiyama, Haotian Cui, Dar’ya S. Redka, Mehran Karimzadeh, Edurne Rujas, Hassaan Maan, Sikander Hayat, Kyle Cheung, Rahul Misra, Joseph B. McPhee, Russell D. Viirre, Andrew Haller, Roberto J. Botelho, Raffi Karshafian, Sarah A. Sabatinos, Gregory D. Fairn, Seyed Ali Madani Tonekaboni, Andreas Windemuth, Jean-Philippe Julien, Vijay Shahani, Stephen S. MacKinnon, Bo Wang, Costin N. Antonescu
Publicado 2021

Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers

por Edurne Rujas, Iga Kucharska, Yong Zi Tan, Samir Benlekbir, Hong Cui, Tiantian Zhao, Gregory A. Wasney, Patrick Budylowski, Furkan Guvenc, Jocelyn C. Newton, Taylor Sicard, Anthony Semesi, Krithika Muthuraman, Amy Nouanesengsy, Clare Burn Aschner, Katherine Prieto, Stephanie A. Bueler, Sawsan Youssef, Sindy Liao-Chan, Jacob Glanville, Natasha Christie-Holmes, Samira Mubareka, Scott D. Gray-Owen, John L. Rubinstein, Bebhinn Treanor, Jean-Philippe Julien
Publicado 2021

The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies.

por Devin Sok, Uri Laserson, Jonathan Laserson, Yi Liu, Francois Vigneault, Jean-Philippe Julien, Bryan Briney, Alejandra Ramos, Karen F Saye, Khoa Le, Alison Mahan, Shenshen Wang, Mehran Kardar, Gur Yaari, Laura M Walker, Birgitte B Simen, Elizabeth P St John, Po-Ying Chan-Hui, Kristine Swiderek, Steven H Kleinstein, Galit Alter, Michael S Seaman, Arup K Chakraborty, Daphne Koller, Ian A Wilson, George M Church, Dennis R Burton, Pascal Poignard
Publicado 2013