Deep generative model embedding of single-cell RNA-Seq profiles on hyperspheres and hyperbolic spaces

Single-cell RNA-seq allows the study of tissues at cellular resolution. Here, the authors demonstrate how deep learning can be used to gain biological insight from such data by accounting for biological and technical variability. Data exploration is improved by accurately visualizing cells on an int...

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Bibliographic Details
Main Authors: Jiarui Ding, Aviv Regev
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Q
Online Access:https://doaj.org/article/050105f7e38d42cba8c66492f371e672
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