EGFR and PDGFRA co-expression and heterodimerization in glioblastoma tumor sphere lines

Abstract Concurrent amplifications of EGFR and PDGFRA have been reported in up to 5% of glioblastoma (GBM) and it remains unclear why such independent amplification events, and associated receptor overexpression, would be adaptive during glioma evolution. Here, we document that EGFR and PDGFRA prote...

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Autores principales: Debyani Chakravarty, Alicia M. Pedraza, Jesse Cotari, Angela H. Liu, Diana Punko, Aushim Kokroo, Jason T. Huse, Gregoire Altan-Bonnet, Cameron W. Brennan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/052b404398294acfaa36d10454862c2e
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