GroEL actively stimulates folding of the endogenous substrate protein PepQ

In the prevailing model for assisted protein folding, chaperonins act passively by preventing protein aggregation. Here, the authors use single-molecule fluorescence measurements and cryo-electron microscopy and show that theE. coliGroELS chaperonin system also has an active role in folding the endo...

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Autores principales: Jeremy Weaver, Mengqiu Jiang, Andrew Roth, Jason Puchalla, Junjie Zhang, Hays S. Rye
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/0541f983daa94abab6070f16ff2a5940
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