PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma

PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma

Resistance to anti-angiogenic therapies often occurs in patients. Here, the authors demonstrate the role of PDGF signaling in GBM resistance to anti-VEGF treatment via a mechanism that involves endothelial-mesenchymal transformation and transcriptional regulation of VEGFR-2.

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Auteurs principaux: Tianrun Liu, Wenjuan Ma, Haineng Xu, Menggui Huang, Duo Zhang, Zhenqiang He, Lin Zhang, Steven Brem, Donald M. O’Rourke, Yanqing Gong, Yonggao Mou, Zhenfeng Zhang, Yi Fan
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Science
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Accès en ligne:https://doaj.org/article/055f0727bcaa4b70a85ef5c46234440d
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Résumé:Resistance to anti-angiogenic therapies often occurs in patients. Here, the authors demonstrate the role of PDGF signaling in GBM resistance to anti-VEGF treatment via a mechanism that involves endothelial-mesenchymal transformation and transcriptional regulation of VEGFR-2.

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