PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma

PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma

Resistance to anti-angiogenic therapies often occurs in patients. Here, the authors demonstrate the role of PDGF signaling in GBM resistance to anti-VEGF treatment via a mechanism that involves endothelial-mesenchymal transformation and transcriptional regulation of VEGFR-2.

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Autores principales: Tianrun Liu, Wenjuan Ma, Haineng Xu, Menggui Huang, Duo Zhang, Zhenqiang He, Lin Zhang, Steven Brem, Donald M. O’Rourke, Yanqing Gong, Yonggao Mou, Zhenfeng Zhang, Yi Fan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
Q
Acceso en línea:https://doaj.org/article/055f0727bcaa4b70a85ef5c46234440d
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spelling oai:doaj.org-article:055f0727bcaa4b70a85ef5c46234440d2021-12-02T17:33:17ZPDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma10.1038/s41467-018-05982-z2041-1723https://doaj.org/article/055f0727bcaa4b70a85ef5c46234440d2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05982-zhttps://doaj.org/toc/2041-1723Resistance to anti-angiogenic therapies often occurs in patients. Here, the authors demonstrate the role of PDGF signaling in GBM resistance to anti-VEGF treatment via a mechanism that involves endothelial-mesenchymal transformation and transcriptional regulation of VEGFR-2.Tianrun LiuWenjuan MaHaineng XuMenggui HuangDuo ZhangZhenqiang HeLin ZhangSteven BremDonald M. O’RourkeYanqing GongYonggao MouZhenfeng ZhangYi FanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tianrun Liu
Wenjuan Ma
Haineng Xu
Menggui Huang
Duo Zhang
Zhenqiang He
Lin Zhang
Steven Brem
Donald M. O’Rourke
Yanqing Gong
Yonggao Mou
Zhenfeng Zhang
Yi Fan
PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma
description Resistance to anti-angiogenic therapies often occurs in patients. Here, the authors demonstrate the role of PDGF signaling in GBM resistance to anti-VEGF treatment via a mechanism that involves endothelial-mesenchymal transformation and transcriptional regulation of VEGFR-2.
format article
author Tianrun Liu
Wenjuan Ma
Haineng Xu
Menggui Huang
Duo Zhang
Zhenqiang He
Lin Zhang
Steven Brem
Donald M. O’Rourke
Yanqing Gong
Yonggao Mou
Zhenfeng Zhang
Yi Fan
author_facet Tianrun Liu
Wenjuan Ma
Haineng Xu
Menggui Huang
Duo Zhang
Zhenqiang He
Lin Zhang
Steven Brem
Donald M. O’Rourke
Yanqing Gong
Yonggao Mou
Zhenfeng Zhang
Yi Fan
author_sort Tianrun Liu
title PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma
title_short PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma
title_full PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma
title_fullStr PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma
title_full_unstemmed PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma
title_sort pdgf-mediated mesenchymal transformation renders endothelial resistance to anti-vegf treatment in glioblastoma
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/055f0727bcaa4b70a85ef5c46234440d
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