Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation

Mutations in homology-directed repair genes likeBRCA2are linked to breast cancer susceptibility. Here the authors generate mice with an inducible DNA break-reporter system and see high levels of homology-directed repair in proliferative mammary tissue and a general reliance on BRCA2 in various tissu...

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Autores principales:	Elizabeth M. Kass, Pei Xin Lim, Hildur R. Helgadottir, Mary Ellen Moynahan, Maria Jasin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/05628ecc62f8432486b6a2626164ba2c
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spelling	oai:doaj.org-article:05628ecc62f8432486b6a2626164ba2c2021-12-02T14:38:56ZRobust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation10.1038/ncomms132412041-1723https://doaj.org/article/05628ecc62f8432486b6a2626164ba2c2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13241https://doaj.org/toc/2041-1723Mutations in homology-directed repair genes likeBRCA2are linked to breast cancer susceptibility. Here the authors generate mice with an inducible DNA break-reporter system and see high levels of homology-directed repair in proliferative mammary tissue and a general reliance on BRCA2 in various tissues.Elizabeth M. KassPei Xin LimHildur R. HelgadottirMary Ellen MoynahanMaria JasinNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elizabeth M. Kass Pei Xin Lim Hildur R. Helgadottir Mary Ellen Moynahan Maria Jasin Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation
description	Mutations in homology-directed repair genes likeBRCA2are linked to breast cancer susceptibility. Here the authors generate mice with an inducible DNA break-reporter system and see high levels of homology-directed repair in proliferative mammary tissue and a general reliance on BRCA2 in various tissues.
format	article
author	Elizabeth M. Kass Pei Xin Lim Hildur R. Helgadottir Mary Ellen Moynahan Maria Jasin
author_facet	Elizabeth M. Kass Pei Xin Lim Hildur R. Helgadottir Mary Ellen Moynahan Maria Jasin
author_sort	Elizabeth M. Kass
title	Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation
title_short	Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation
title_full	Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation
title_fullStr	Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation
title_full_unstemmed	Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation
title_sort	robust homology-directed repair within mouse mammary tissue is not specifically affected by brca2 mutation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/05628ecc62f8432486b6a2626164ba2c
work_keys_str_mv	AT elizabethmkass robusthomologydirectedrepairwithinmousemammarytissueisnotspecificallyaffectedbybrca2mutation AT peixinlim robusthomologydirectedrepairwithinmousemammarytissueisnotspecificallyaffectedbybrca2mutation AT hildurrhelgadottir robusthomologydirectedrepairwithinmousemammarytissueisnotspecificallyaffectedbybrca2mutation AT maryellenmoynahan robusthomologydirectedrepairwithinmousemammarytissueisnotspecificallyaffectedbybrca2mutation AT mariajasin robusthomologydirectedrepairwithinmousemammarytissueisnotspecificallyaffectedbybrca2mutation
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Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation

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