Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation

Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation

Mutations in homology-directed repair genes likeBRCA2are linked to breast cancer susceptibility. Here the authors generate mice with an inducible DNA break-reporter system and see high levels of homology-directed repair in proliferative mammary tissue and a general reliance on BRCA2 in various tissu...

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Autores principales: Elizabeth M. Kass, Pei Xin Lim, Hildur R. Helgadottir, Mary Ellen Moynahan, Maria Jasin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/05628ecc62f8432486b6a2626164ba2c
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