Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice.
<h4>Background</h4>It has been well documented that phosphodiesterase-5 inhibitor, sildenafil (SIL) protects against myocardial ischemia/reperfusion (I-R) injury. SIRT1 is part of the class III Sirtuin family of histone deacetylases that deacetylates proteins involved in cellular stress...
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Autores principales: | , , , , , |
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Formato: | article |
Lenguaje: | EN |
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Public Library of Science (PLoS)
2014
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Acceso en línea: | https://doaj.org/article/05908ba017504837bc2a445f15aac99f |
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