BiP Heterozigosity Aggravates Pathological Deterioration in Experimental Amyotrophic Lateral Sclerosis

BiP Heterozigosity Aggravates Pathological Deterioration in Experimental Amyotrophic Lateral Sclerosis

In the present study, we investigated the involvement of the chaperone protein BiP (also known as GRP78 or Hspa5), a master regulator of intracellular proteostasis, in two mouse models of neurodegenerative diseases: amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). To this end, we us...

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Detalles Bibliográficos
Autores principales: Marta Gómez-Almería, Sonia Burgaz, Carlos Costas-Insua, Carmen Rodríguez-Cueto, Irene Santos-García, Ignacio Rodríguez-Crespo, Concepción García, Manuel Guzmán, Eva de Lago, Javier Fernández-Ruiz
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
cannabinoids
CB<sub>1</sub> receptors
BiP interactor protein
BiP<sup>+/−</sup> mice
mSOD1 mice
amyotrophic lateral sclerosis
Biology (General)
QH301-705.5
Chemistry
QD1-999
Acceso en línea:https://doaj.org/article/0596c9acd46f48c0a93625dc3145c5b7
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https://doaj.org/article/0596c9acd46f48c0a93625dc3145c5b7

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